P120 CATENIN-MEDIATED STABILIZATION OF E-CADHERIN IS ESSENTIAL FOR PRIMITIVE ENDODERM SPECIFICATION.



Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

Abstract Background Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies.Hence, targeting both IGF1R and Src concurrently is one of the main challenges in combating resistance t

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